DHEA (dehydroepiandrosterone) is a natural
hormone responsible for many vital functions
in the body. However, its production declines
with age and low levels of DHEA have been
linked to lack of energy, loss of memory,
and decreased immunity. Interestingly
enough, those with fibromyalgia experience
many of these same symptoms.
Futhermore, DHEA has been found to be
lower in some fibromyalgia patients and
since low levels of DHEA have corresponded
with high pain levels, it may be helpful
for this particular symptom.
7 Keto
DHEA vs. DHEA
Before its active metabolite 7-Keto DHEA was discovered,
supplementation with DHEA had mixed results. But 7-Keto
DHEA has all the benefits of its parent compound,
without the downside. It has been shown to help retain
and enhance the neurological and immunological activity
of DHEA, but cannot be metabolized into unwanted testosterone
or estrogens, an important factor for those who have
concerns about increased levels of these hormones,
such as fibromyalgia sufferers who are estrogen dominant.
Researchers have now identified 7-Keto DHEA as an
active ingredient of DHEA. When tested, it significantly
outperformed its parent compound (DHEA). Animal studies
found 7-Keto DHEA to be 2.5 times more active than
DHEA at increasing liver thermogenic enzymes. Optimal
mitochondrial enzyme activity is crucial to the production
of cellular energy for mental and physical activity.
This can be especially important to those with fibromyalgia.
DHEA and Immunity
7 Keto DHEA has been shown to help boost the immune
system by increasing the production of specialized
white blood cells. Since some health professionals
feel that there may be an autoimmune component involved
in fibromyalgia conditions, increasing DHEA levels
may be beneficial.
Furthermore, a study presented in April of 2004 and
reported from the Minnesota Applied Research Center
and the Geriatric Research Education and Clinical
Center in Minneapolis found that 7-KETO supplementation
improved immune function in elderly men and women.
This randomized, double-blind, placebo-controlled
study involved 22 women and 20 men over the age of
65. They were given 100 mg of 7-KETO twice daily,
or a placebo, for four weeks. Researchers noted that
patients in the 7-KETO group had a significant increase
in immune helper cells and a significant decrease
in immune suppressor cells. There is also an increase
in neutrophils-white blood cells that are the first
to respond to infection. 1
References
- Zenk JL, Kuskowski MA. The use
of 3-acetyl-7-oxo-dehydroepiandrosterone for augmenting
immune response in the elderly. Presented at meeting
of FASEB, April 17, 2004.
Supplement Facts
Capsules per Container: 30 Tablets, 50 mg
Serving Size: One (1) Tablet
Servings per Container: 30
Suggested Use: 1 tablet daily
Supplement Facts for 50 mg
Tablet
Serving Size: 1 tablet(s) |
Amount per Serving |
% Daily Value |
| 7-oxo DHEA acetate |
|
† |
|
† Daily Value not established.
Other Ingredients: microcrystalline cellulose,
stearic acid, modified cellulose gum, and colloidal
silicon dioxide.
Suitable for vegetarians and HYPOALLERGENIC.
Contains no yeast, dairy, egg, gluten, corn, soy or
wheat. Contains no sugar, starch, salt, preservatives,
or artificial color, flavor or fragrance.
7-KetoTM is a Trademark of Humanetics
Corporation.
Warning:If you are pregnant, breastfeeding,
or taking any medication, consult your health care
professional before using this product. Do not use
if either tamper-evident seal is broken or missing.
Keep out of the reach of children.
Manufactured by Source Naturals
The Benefits of 7-Keto DHEA
7-Keto DHEA is considered by nutritional scientists
to be among the most effective compounds for anti-aging
and health. Produced in the body, DHEA (dehydroepiandrosterone)
is a natural hormone responsible for many vital functions
in the body. Its production declines with age, however,
and low levels of DHEA have been linked to lack of
energy, loss of memory, and decreased immunity.
Before its active metabolite 7-Keto DHEA was discovered,
supplementation with DHEA had mixed results. However,
current research has shown that 7-Keto DHEA has all
the benefits of its parent compound (DHEA), without
the downside. 7-Keto DHEA retains and enhances the
thermogenic, neurological, and immunological activity
of DHEA, but cannot be metabolized into unwanted testosterone
or estrogens.
A safe and more active form of an essential hormone,
Source Naturals 7-Keto DHEA is nutritional science
at its best—quality you can trust to help protect
against the ravages of time.
Beneficial Functions
of DHEA
The most plentiful adrenal steroid in the blood of
humans, DHEA (dehydroepiandrosterone) is manufactured
in the adrenal glands, as well as in the testes and
in the brain. Produced abundantly during youth, DHEA
levels peak at about age 25, but decrease by more
than 50% at around age 55. Because DHEA is integral
to such a wide variety of important functions, this
decline may leave the body vulnerable to various health
problems.
Researchers have discovered critical links between
DHEA and improvement in:
- Brain function
- Immune function
- Bone deposition
- Cardiovascular health
- Percentage of muscle mass
- A decrease in the percentage of body
fat
DHEA plays a role in controlling age-related increases
in blood glucose and insulin resistance, a crucial
factor in maintaining youthful tissues in the circulatory
system. Elderly patients with cognitive difficulties
had significantly lower blood levels of DHEA than
control groups. Supplemental DHEA was shown to increase
physical and psychological well-being in men and women,
including better sleep and ability to handle stress.
DHEA’s diverse biological activities may result
from its anti-cortisol action. Cortisol is produced
by the adrenal glands in response to stress, but our
stress-inducing culture is causing a vast overload
of cortisol in many people. This excess cortisol can
damage cells and tissues, contributing to the aging
process.
7-Keto DHEA is More
Active than DHEA
Researchers have identified 7-Keto DHEA as an active
ingredient of DHEA. When tested, it significantly
outperformed its parent compound. Animal studies found
7-Keto DHEA to be 2.5 times more active than DHEA
at increasing liver thermogenic enzymes. Optimal mitochondrial
enzyme activity is crucial to the production of cellular
energy for mental and physical activity. As an active
inducer of thermogenic enzymes, 7-Keto DHEA provides
support for dieting or strength training.
7-Keto DHEA and Sex
Hormones
Although DHEA is an intermediate in the biosynthesis
of estrogens and testosterone, 7-Keto DHEA is not.
Therefore 7-Keto DHEA cannot be metabolized into active
estrogenic or androgenic sex hormones and does not
cause the imbalances and undesirable side effects
of its parent compound.
A Safe Strategy to Aging
Well
Research has shown that supplementation of 7-Keto
DHEA is well tolerated. Evaluated for safety in human
clinical trials and animal studies, 7-Keto DHEA had
no adverse effects, even at doses up to 200 mg/day.
Adding Source Naturals 7-Keto DHEA to your supplement
regimen is a profound yet easy way to minimize the
wear and tear over time on your body, and has the
potential to put more life in your years.
References
Bobyleva, V. et al. 1997. The Effects of the Ergosteroid
3-Acetyl-7-Oxo-Dehydroepiandrosterone on mitochondrial
membrane potential: possible relationship to thermogenesis.
Arch Biochem and Biophys 341:122-128.
Lardy, H. et al. 1998. Ergosteroids 3 II: Biologically
active metabolites and synthetic derivatives of dehydroepiandrosterone.
Steroids 63:158-65.
Lardy, H. et al. 1995. Ergosteroids: Induction of
thermogenic enzymes in liver of rats treated with
steroids derived from DHEA. Proc Natl Acad Sci 92:6617-6619.
Morales, A. et al. 1994. Effects of replacement dose
of dehydroepiandrosterone in men and women of advancing
age. J Clin Endocrinol Metab 78:1360-67.
