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Magnesium Malate
Soothes Muscles by Supporting
Energy Production
by Source Naturals
Magnesium is an essential mineral that
is necessary for the proper functioning
of all muscles. It is needed by every
cell of your body to help maintain normal
cardiovascular, muscle, nerve, bone, and
cellular function. And, it can also help
relieve muscle spasms, pain, and constipation.
Malic acid is found in abundance in apples
and other fruits. It is also found in
the cells of plants and animals, including
humans. This nutrient plays a key role
in the production of energy in the cells,
also known as ATP. Therefore, it is often
recommended with magnesium for fibromyalgia
and chronic fatigue syndrome.
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Magnesium
and Malic Acid for Fibromyalgia
Recent studies have indicated that those with Fibromyalgia
tend to have decreased levels of magnesium in comparison
to the control groups. According to a study published in the Journal
of Nutritional Medicine, Abraham et al hypothesized
that a magnesium deficiency found in muscles cells
could possibly play a role in the development of Fibromyalgia.
The group demonstrated that a daily supplement of
300-600 of Magnesium Malate resulted in improvements
of symptoms, as well as in the number and severity
of tender points.
Magnesium is an essential mineral in over 300 enzymatic
reactions in metabolism. These reactions include those
involved in the Krebs cycle (one of the body's energy
production systems), such as:
- DNA metabolism
- Vital for cell formation
- Activation of B vitamins
- Energy transport and storage
- The breakdown of fatty acids
- Proper nerve function and neurotransmitter
activity
- The formation and maintenance of protein,
fatty acids, and bone.
- The formation of adenosine triphosphate
(ATP), the body's energy source.
Magnesium Malate is a highly absorbable form of magnesium
that provides the benefits of this mineral, along
with the benefits of malic acid, a nutrient found
to contribute to the process of transforming food
into ATP, the body's energy source. Many fibromyalgia
sufferers have stated that the combination of magnesium
and malic acid have been helpful for their symptoms
associated with fibromyalgia.
Magnesium
Malate and Fibromyalgia
The cause of fibromyalgia is not
fully understood. However, some leading fibromyalgia
researchers believe that there is a malfunction in
the body's ability to manufacture energy. The muscles
burn energy faster than it can be produced, which
is compounded by a shortage of the nutrients necessary
to make the energy. This may cause the muscles to
rely too heavily on the inefficient (anaerobic) energy
cycle for much of their energy production instead
of the more efficient (aerobic) energy cycle. Malic
acid plays a key role in the production of energy
in the cells; therefore, it is often recommended with
magnesium for fibromyalgia and chronic fatigue syndrome.
Some fibromyalgia
patients may be magnesium deficient. An article in
the Journal of Nutritional Medicine pointed out that
many fibromyalgia patients have responded quite favorably
to magnesium malate. Magnesium and malic acid are
important substances in the manufacture of energy
for the human muscle cell.
Case Studies: Magnesium and Malic Acid to Reduce
Fibromyalgia Pain
In a 1992 study 15 fibromyalgia patients received
an oral dose of 1200-2400 mg of malate (malic acid)
and 300-600 mg of magnesium over a four and 8 week
period. Patients reported a reduction in pain across
a tender point index (TPI). Six subjects felt an improvement
in 48 hours.
During another study conducted in 1995, researchers
gave 24 subjects with fibromyalgia a low tablet with
50 mg magnesium and 200 mg malic acid. Scientists
measured pain levels through patient self-assessment
and the tender point index. Results showed that the
low dose, short term trial was not effective to reduce
fibromyalgia pain. However, higher doses over an extended
duration significantly reduced subjects' pain.
Clinical Trial: Magnesium
Malate and Fibromyalgia
There are many people with fibromyalgia that have
reported positive benefits from taking magnesium in
combination with malic acid, as well as studies to
back them up. For example:
In a randomized, placebo-controlled, open-label,
crossover trial (grade I evidence-based), Abraham
et al used a combination of magnesium (300-600 mg)
and malate (1,200-2,400 mg) in 15 patients during
an eight-week period. The results showed a statistically significant
clinical improvement (P < 0.001) in the treatment
group vs. placebo as measured by two outcomes. TPI
scores (± SE) of 19.6 ± 2.1 prior
to treatment decreased to 8 ± 1.1 and 6.5
± 0.74 at four and eight weeks, respectively,
on the mag-malate combination. Conversely, following
an average of eight weeks, six patients were switched
to placebo for two weeks. Their TPI scores increased
significantly (P < 0.001) from 6.8 ± 0.75
to 21.5 ± 1.4. Subjective improvement of
fibromyalgia symptoms occurred within 48 hours of
magnesium supplementation in the mag-malate group;
symptoms worsened in the placebo group.
Many practitioners have found it to be useful in
a pain reduction regimen for this disease at a higher
dosage (up to 600 mg magnesium and 2,400 mg malic
acid).
More About Magnesium
Malate
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Supplement Facts
Capsules per Container: 200 Capsules, 625 mg
Serving Size: Six (6) Capsules
Servings per Container: 33
Suggested Use: 6 capsules daily
Supplement Facts for 625 mg
Capsule
Serving Size: 6 capsule(s) |
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Amount |
%DV* |
| Calories
Total Carbohydrates
Dietary Fiber
Protein
Magnesium (as magnesium malate)
Malic Acid (as magnesium malate
and malic acid) |
10
3 g
1 g
1 g
433 mg
2.5 g |
**
<2%
4%
2%
110%
† |
|
* Percent Daily Values (%DV) are based
on a 2,000 calorie diet.
** Daily Value not established.
Other Ingredients: gelatin (capsule),
microcrystalline cellulose, magnesium stearate, and
colloidal silicon dioxide.
Hypoallergenic: Contains no yeast, dairy,
egg, gluten, corn, soy, or wheat. Contains no sugar,
starch, salt, preservatives, artificial colors, flavor,
or fragrance.
Warning: If you are pregnant, may become
pregnant, or breastfeeding, consult your health care
professional before using this product. Do not use
if either tamper-evident seal is broken or missing.
Keep out of the reach of children.
Manufactured by Source Naturals
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Magnesium
Malate
Soothes Muscles by Supporting Energy Production
by Source Naturals
200 Capsules, 625 mg
$10.99 - Discount Price
(Retail Price $17.50 - Save 37%)
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References
1. Prescott EE, et al. Red blood
cell magnesium and fibromyalgia. Scand J Rheum 1992;
94:31.
2. Abraham GE, Glechas ID. Management
of fibromyalgia: A rationale for the use of magnesium
and malic acid. J Nutr Med 1992; 3:49-59.
3. Abraham GE, Glechas ID. Management
of fibromyalgia: A rationale for the use of magnesium
and malic acid. J Nutr Med 1992;3:49-59.
4. Croftord LJ, Appleton BE. Complementary
and alternative therapies for fthrornyalgia. Curr
Rlteurnatol Rep 2001 Apr;3(2): 147-56 Source: (http://www.tsangenterprise.com/malicmag.htm)
5. Friedberg F, Jason IA. Chronic
fatigue syndrome and Palm O, Mourn B, Jahnsen J, Gran
JT. Fibromyalgia and chronic widespread pain in patients
with inflammatory bowel disease: a cross sectional
population survey. J Rheumatol 2001 Mar;28(3):590-4
6. Russell J, Michalek J, Flechas
J, et al. Treatment of fibromyalgia syndrome with
SuperMalic: A randomized, double-blind, placebo-controlled,
crossover pilot study. J Rheumatol 1995;22(5):953-
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